ARTIFICIAL INTELLIGENCE

Deep learning tools for dentomaxillofacial application

The rationale behind this topic:

The use of Artificial Intelligence methods in dental practice, such as deep learning, brings new perspectives for the diagnosis, classification and prediction of oral diseases, for treatment planning, and for the evaluation and prediction of outcomes. Deep convolutional neural networks hold promise to improve both quality and quantity of future image processing, and may help radiologists to analyze images that contain vast data information This project aims to evaluate the performance of combined deep convolutional neural networks for automatic tooth segmentation on dental panoramic radiographs (2D segmentation) and on CBCT scans (3D Segmentation).

contact:

Professor Reinhilde Jacobs

reinhilde.jacobs@uzleuven.be

Related projects


Project 1: Accurate and fast deep learning tool for tooth detection and segmentation on panoramic radiographs


Researchers: André Ferreira Leite, Adriaan Van Gerven, Holger Willems, Thomas Beznik, Pierre Lahoud, Hugo Gaêta-Araujo, Myrthel Vranckx, Reinhilde Jacobs


Published on:

Leite AF, Gerven AV, Willems H, Beznik T, Lahoud P, Gaêta-Araujo H, Vranckx M, Jacobs R. Artificial intelligence-driven novel tool for tooth detection and segmentation on panoramic radiographs. Clin Oral Investig. 2020 Aug 26. doi: 10.1007/s00784-020-03544-6. Epub ahead of print. PMID: 32844259.


Project 2: AI-driven molar angulation measurements to predict third molar eruption on panoramic radiographs


Researchers: Myrthel Vranckx, Adriaan Van Gerven, Holger Willems, Arne Vandemeulebroucke, André Ferreira Leite, Constantinus Politis, Reinhilde Jacobs


Published on:

Vranckx M, Van Gerven A, Willems H, Vandemeulebroucke A, Ferreira Leite A, Politis C, Jacobs R. Artificial Intelligence (AI)-Driven Molar Angulation Measurements to Predict Third Molar Eruption on Panoramic Radiographs. Int J Environ Res Public Health. 2020 May 25;17(10):3716. doi: 10.3390/ijerph17103716. PMID: 32466156; PMCID: PMC7277237.

Project 3: A novel artificial intelligence tool for accurate tooth segmentation on CBCT


Researchers: Pierre Lahoud, Mostafa EzEldeen, Thomas Beznik, Holger Willems, André Ferreira Leite, Adriaan Van Gerven, Reinhilde Jacobs


Published on:

Lahoud P, EzEldeen M, Beznik T, Willems H, Leite A, Van Gerven A, et al. Artificial intelligence for fast and accurate 3D tooth segmentation on CBCT. J Endod. 2021 Jan.

Project 4: Automatic segmentation of the pharyngeal airway space with convolutional neural network


The rationale behind this topic:

Pharyngeal airway space assessment has been an area of interest for clinicians allowing efficient diagnosis, treatment planning and follow-up of patients with dento-skeletal deformities and obstructive sleep apnea which might influence the dimensions of upper airway space. Recently, deep learning convolutional neural networks (CNNs), has gained much attention in the dentomaxillofacial field for segmenting and evaluating the airway space. This project aims to propose and investigate the performance of a deep learning-based 3D CNN model for PAS segmentation from CT/CBCT images.


Researchers: Sohaib Shujaat, Omid Jazil, Holger Willems, Adriaan Van Gerven, Eman Shaheen, Constantinus Politis, Reinhilde Jacobs.


Published on:

Shujaat S, Jazil O, Willems H, Van Gerven A, Shaheen E, Politis C, Jacobs R. Automatic segmentation of the pharyngeal airway space with convolutional neural network. J Dent. 2021 May;103705. doi: 10.1016/j.jdent.2021.103705.


Project 5: Development and validation of a novel artificial intelligence driven tool for accurate mandibular canal segmentation on CBCT


The objective of this study is the development and validation of a novel artificial intelligence driven tool for fast and accurate mandibular canal segmentation on cone beam computed tomography (CBCT).
Given the importance of adequate pre-operative mandibular canal assessment, Artificial Intelligence could help relieve practitioners from the delicate and time-consuming task of manually tracing and segmenting this structure, helping prevent per- and post-operative neurovascular complications.


Researchers: Pierre Lahoud, Siebe Diels, Liselot Niclaes, Stijn Van Aelst, Holger Willems, Adriaan Van Gerven, Marc Quirynen, Reinhilde Jacobs.


Published on:

Lahoud P, Diels S, Niclaes L, Van Aelst S, Willems H, Van Gerven A, Quirynen M, Jacobs R. Development and validation of a novel artificial intelligence driven tool for accurate mandibular canal segmentation on CBCT. J Dent. 2022 Jan;116:103891. doi: 10.1016/j.jdent.2021.103891. Epub 2021 Nov 13. PMID: 34780873.


Project 6: Influence of dental fillings on the performance of a novel artificial intelligence-driven tool for automatic tooth segmentation on CBCT images


Tooth segmentation is a challenging and time-consuming task, mainly in the presence of artifacts generated by dental filling material. The proposed AI-driven tool could offer a clinically acceptable approach for tooth segmentation, to be applied in the digital dental workflows considering its time efficiency and high accuracy even in the presence of artifacts generated from dental fillings. 


Researchers: Rocharles Cavalcante Fontenele, Maurício do Nascimento Gerhardt, Jáder Camilo Pintom, Adriaan Van Gerven, Holger Willems, Reinhilde Jacobs, Deborah Queiroz Freitas


Published on:

Fontenele RC, Gerhardt MDN, Pinto JC, Van Gerven A, Willems H, Jacobs R, Freitas DQ. Influence of dental fillings and tooth type on the performance of a novel artificial intelligence-driven tool for automatic tooth segmentation on CBCT images - A validation study. J Dent. 2022 Feb 18;119:104069. doi: 10.1016/j.jdent.2022.104069. Online ahead of print. PMID: 35183696


Project 7: Layered deep learning for automatic mandibular segmentation in cone-beam computed tomography


The aim of this project was to develop and validate a layered deep learning algorithm that automatically creates 3D surface models of the human mandible from a CBCT scan. The hypothesis was that such an AI model could provide accurate 3D surface models of the mandible in a more reliable and time efficient way than the current clinical standard, being semi-automatic segmentation. At the end of this project, we established that a layered 3D U-Net architecture deep learning algorithm, with and without additional user refinements, improved time-efficiency, reduced operator error, and provided excellent accuracy when benchmarked against the clinical standard, being semi-automatic segmentation.


Researchers: Pieter-Jan Verhelst, Andreas Smolders, Thomas Beznik, Jeroen Meewis, Arne Vandemeulebroucke, Eman Shaheen, Adriaan Van Gerven, Holger Willems, Constantinus Politis, Reinhilde Jacobs


Published on:

Verhelst PJ, Smolders A, Beznik T, Meewis J, Vandemeulebroucke A, Shaheen E, Van Gerven A, Willems H, Politis C, Jacobs R. Layered deep learning for automatic mandibular segmentation in cone-beam computed tomography. J Dent. 2021 Nov;114:103786. doi: 10.1016/j.jdent.2021.103786. Epub 2021 Aug 20. PMID: 34425172​


Image_layered deep learning
Visual_layered deep learning

Project 8: A novel deep learning system for multi-class tooth segmentation and classification on cone beam computed tomography. A validation study


Automatic tooth segmentation and classification from cone beam computed tomography (CBCT) have become an integral component of the digital dental workflows. Therefore, we developed and validated a deep learning approach for automatic tooth segmentation and classification from CBCT images with a dataset of 186 scans acquired with 2 different CBCT machines. The AI framework correctly segmented teeth with optimal precision (0.98±0.02) and 1800 times faster compared to an expert. Teeth classification also performed optimally with precision of 97.9%.

The proposed 3D U-Net based AI framework is an accurate and time-efficient deep learning system for automatic tooth segmentation and classification without expert refinement which indicates its potential future applications for diagnostics and treatment planning in the field of digital dentistry, while reducing clinical workload.


Researchers: Eman Shaheen, André Leite, Khalid Ayidh Alqahtani, Andreas Smolders, Adriaan Van Gerven, Holger Willems, Reinhilde Jacobs


Published on:

Shaheen E, Leite A, Alqahtani KA, Smolders A, Van Gerven A, Willems H, Jacobs R. A novel deep learning system for multi-class tooth segmentation and classification on cone beam computed tomography. A validation study. J Dent. 2021 Dec;115:103865. doi: 10.1016/j.jdent.2021.103865. Epub 2021 Oct 26. PMID: 34710545​


Shaheen_AI 1
Shaheen_AI 2
Shaheen_AI 3

Project 9: Automated detection and labelling of teeth and small edentulous regions on cone-beam computed tomography using convolutional neural networks


This paper focuses on the accuracy of AI to identify and label teeth and missing teeth in small edentulous areas. Results showed excellent accuracy to perform both tasks in a fast manner. AI may represent a promising time-saving tool for radiological reporting, automated dental charting and surgical and treatment planning.


Researchers: Maurício do Nascimento Gerhardt, Rocharles Cavalcante Fontenele, André Ferreira Leite, Pierre Lahoud, Adriaan Van Gerven, Holger Williems, Andreas Smolders, Thomas Beznik, Reinhilde Jacobs


Published on:

Gerhardt MDN, Fontenele RC, Leite AF, Lahoud P, Van Gerven A, Willems H, Smolders A, Beznik T, Jacobs R. Automated detection and labelling of teeth and small edentulous regions on cone-beam computed tomography using convolutional neural networks. J Dent. 2022 Apr 21;122:104139. doi: 10.1016/j.jdent.2022.104139. Epub ahead of print. PMID: 35461974.


Project 10: Convolutional neural network for automatic maxillary sinus segmentation on cone-beam computed tomographic images


An accurate three-dimensional (3D) segmentation of the maxillary sinus is crucial for multiple diagnostic and treatment applications including implant placement, sinus floor elevation, removal of (impacted) posterior teeth and/or root remnants, and orthognathic surgical procedures. Yet, it is challenging and time-consuming when manually performed on CBCT dataset. Recently, convolutional neural networks (CNNs) have proven to provide excellent performance in the field of 3D image analysis. Hence, this study developed and validated a novel automated CNN-based methodology for the segmentation of maxillary sinus using CBCT images. ​The proposed model provided a time-efficient, precise, and consistent automatic segmentation which could allow an accurate generation of 3D models for diagnosis and virtual treatment planning.


Researchers: Nermin Morgan, Adriaan Van Gerven, Andreas Smolders, Karla de Faria Vasconcelos, Holger Willems, Reinhilde Jacobs​


Published on:

Morgan N, Van Gerven A, Smolders A, de Faria Vasconcelos K, Willems H, Jacobs R. Convolutional neural network for automatic maxillary sinus segmentation on cone-beam computed tomographic images. Sci Rep. 2022 May 7;12(1):7523. doi: 10.1038/s41598-022-11483-3. PMID: 35525857; PMCID: PMC9079060.


Book chapters


Artificial Intelligence in Medicine (AIM)


Researchers: Maurício do Nascimento Gerhardt, Sohaib Shujaat, Reinhilde Jacobs


Published on:

do Nascimento Gerhardt M., Shujaat S., Jacobs R. (2021) AIM in Dentistry. In: Lidströmer N., Ashrafian H. (eds) Artificial Intelligence in Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-58080-3_319-1


Abstract:

The steep rise of digital dentistry and technological advancements have opened doors for the development of artificial intelligence (AI). For the past few years, AI-based applications in dentistry have been constantly evolving as highlighted by the increasing number of studies, and now it is slowly entering the clinical arena. As healthcare professionals, dentists need to diagnose, plan, and make clinical decisions in order to provide an adequate treatment and care for their patients. All these phases are time-consuming, observer-dependent, and subjected to human error. Currently, the studies applying AI in many dental specialties have validated its application for the purpose of diagnosis and clinical decision-making. Thus, the objective of AI is to combine the professional expertise with the computer-assisted systems to automatize complex tasks, mimic human cognitive skills, and retrieve information from digital data. Dental AI applications can be advantageous for all dental specialties including dentomaxillofacial radiology, restorative dentistry, oral and maxillofacial surgery, orthodontics, periodontics, prosthodontics, endodontics, and forensic dentistry.

This chapter provides an overview of the current state of the art of the AI applications in dentistry and its specialties.