DIMITRA
Dentomaxillofacial paediatric imaging: an investigation towards low dose radiation induced risks
PROJECT
Open Project for the European Radiation Research Area
GRANT AGREEMENT NUMBER
604984
DURATION
48 months
START
01/06/2014
Notice of transfer:
The information below was previously hosted on https://dimitra.be/
Partners:
- Katholieke Universiteit Leuven - Belgium
- Université Paris Descartes Sorbonne-Paris Cité - France
- Belgian Nuclear Research Centre SCK•CEN - Belgium
- Iuliu Hatieganu University of Medicine and Pharmacy - Romania
Open Project for the European Radiation Research Area
This project focuses on the uncertainties associated with radiation-induced health risks at low doses in paediatric dentistry. It is a multidisciplinary effort to approach the involved risks through four different yet interrelated tasks: radiobiological characterization, dosimetric quantification, epidemiological surveying and image quality & dose optimization.
Research background
Cone Beam Computed Tomography (CBCT) is an emerging X‐ray technology that has found wide applications in dentomaxillofacial imaging. The ability to provide high‐resolution 3D images has resulted in a significant increase in the volume of dental radiology procedures. Although CBCT is associated with higher radiation risk to the patient than conventional dental X-ray imaging (intraoral or panoramic), it is considered to be ‘low dose’ imaging as defined by the High Level Expert Group (HLEG; www.hleg.de) with doses ranging from a few μSv to 1 mSv per examination. This proposal is set to tackle important issues raised by the HLEG and the MELODI (Multidisciplinary European Low Dose Initiative) platform. In particular, as deduced by the name DIMITRA (Dentomaxillofacial paediatric imaging: an investigation towards low dose radiation induced risks), the project focuses on the uncertainties associated with radiation‐induced health risks at low doses in paediatric dentistry and is a multidisciplinary effort to approach the involved risks from different yet interrelated perspectives: radiobiological characterisation, dosimetric quantification, epidemiological surveying and image quality & dose optimization. A unique Monte Carlo (MC) framework will be used to accurately calculate organ doses in dental CBCT imaging, to quantify the radiation induced risk and to feed the radiobiology team with the appropriate data towards the identification, development and validation of biomarkers for radiation induced health effects. Furthermore, it will constitute the basis upon setting up a gender- and age-related epidemiology study. The balance between image quality and dose levels will be explored aiming at reducing the risk through image quality optimization. It is expected that DIMITRA`s outcomes and deliverables will lead to further recommendations and potential future adaptations for the use of CBCT in paediatric dentistry.
Dimitra Research Group
Reinhilde Jacobs
Hilde Bosmans
Ria Bogaerts
Constantinus Politis
Andreas Stratis
Karla de Faria Vasconcelos
Ruben Pauwels
Laura Nicolielo
Guozhi Zhang
Els Tijskens
Myrthel Vranckx
Anna Ockerman
Catalina Moreno
Benjamin Salmon
Anne Caroline Oenning
Catherine Chaussain
Sarah Baatout
Niels Belmans
Marjan Moreels
Mihaela Hedesiu
Pirsoka Virag
Mihaela Baciut
Maria Marcu
Oana Almasan
Raluca Roman
Ioan Barbur
Cristian Dinu
Horatiu Rotaru
Lucia Hurubeanu
Vlad Istouan
Ondine Lucaciu
Daniel Leucuta
Bogdan Crisan
Loredana Bogdan
Ciprian Candea
Simion Bran
Grigore Baciut
Publications
Belmans N, Gilles L, Vermeesen R, Virag P, Hedesiu M, Salmon B, Baatout S, Lucas S, Lambrichts I, Jacobs R, Moreels M; DIMITRA Research Group. Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan. Sci Rep. 2020 Feb 7;10(1):2113. doi: 10.1038/s41598-020-58746-5. PMID: 32034200.
Belmans N.Biological effects of ionizing radiation in medical imaging: A prospective study in children and adults following dental cone-beam computed tomography.Doctoral thesis UHasselt & SCK-CEN. Sep 2019.
Belmans N, Gilles L, Virag P, Hedesiu M, Salmon B, Baatout S, Lucas S, Jacobs R, Lambrichts I, Moreels M. Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations. Dentomaxillofac Radiol. 2019 Sep;48(6):20180428. doi: 10.1259/dmfr.20180428. PMID: 30912976.
Oenning AC, Pauwels R, Stratis A, De Faria Vasconcelos K, Tijskens E, De Grauwe A, Jacobs R, Salmon B; Dimitra research group.Halve the dose while maintaining image quality in paediatric Cone Beam CT.Sci Rep. 2019 Apr 2;9(1):5521. doi: 10.1038/s41598-019-41949-w. PMID:30940872
Hedesiu M, Marcu M, Salmon B, Pauwels R, Oenning AC, Almasan O, Roman R, Baciut M, Jacobs R; DIMITRA Research Group. Irradiation provided by dental radiological procedures in a pediatric population. Eur J Radiol. 2018 Jun;103:112-117. doi: 10.1016/j.ejrad.2018.04.021. Epub 2018 Apr 23.
Marcu M, Hedesiu M, Salmon B, Pauwels R, Stratis A, Oenning ACC, Cohen ME, Jacobs R, Baciut M, Roman R, Dinu C, Rotaru H, Barbur I; DIMITRA Research Group. Estimation of the radiation dose for pediatric CBCT indications: a prospective study on ProMax3D. Int J Paediatr Dent. 2018 Jan 22. doi: 10.1111/ipd.12355
Oenning AC, Jacobs R, Pauwels R, Stratis A, Hedesiu M, Salmon B; DIMITRA Research Group. Cone-beam CT in paediatric dentistry: DIMITRA project position statement. Pediatr Radiol. 2017. https://doi.org/10.1007/s00247-017-4012-9
Oenning AC, Salmon B, Vasconcelos KF, Nicolielo L, Lambrichts I, Sanderink G, Pauwels R; DIMITRA Group, Jacobs R. DIMITRA pediatric skull phantoms: development of age-specific pediatric models for dentomaxillofacial radiology research. Dentomaxillofac Radiol. 2017:20170285. https://doi.org/10.1259/dmfr.20170285
Stratis A, Touyz N, Zhang G, Jacobs R, Bogaerts R, Bosmans H; DIMITRA project partners. Development of a paediatric head voxel model database for dosimetric applications. Br J Radiol. 2017;90:20170051. https://doi.org/10.1259/bjr.20170051
Stratis A, Zhang G, Lopez-Rendon X, Politis C, Hermans R, Jacobs R, Bogaerts R, Shaheen E, Bosmans H. Two examples of indication specific radiation dose calculations in dental CBCT and Multidetector CT scanners. Phys Med. 2017;41:71-77. https://doi.org/10.1016/j.ejmp.2017.03.027
Stratis A, Zhang G, Jacobs R, Bogaerts R, Bosmans H. Rotating and translating anthropomorphic head voxel models to establish an horizontal Frankfort plane for dental CBCT Monte Carlo simulations: a dose comparison study. Phys Med Biol. 2016;61:N681-N696. https://doi.org/10.1088/1361-6560/61/24/N681
RESEARCH COORDINATOR
Prof. dr. Reinhilde Jacobs
ADMINISTRATIVE COORDINATOR
Nele Vanloocke
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